| Purpose:Analyze the incidence and profile of uveal melanoma in the United States from 2001 – 2017 using the combined Surveillance, Epidemiology, and End Results (SEER) and National Program of Cancer Registries (NPCR) database.Materials and Methods: Patient cases were identified using the International Classification of Disease (ICD) for Oncology codes C69.0-6,8,9, C44.0-9, and histology categorization codes 8720-8790/3. Statistical calculations and analyses were performed with the standard functions of the SEER*Stat software and statistical functions in Microsoft Excel.Results:There were a total of 35,457 cases of uveal melanoma from 2001 – 2017. The mean age-adjusted incidence was 6.3 per million (95% CI 6.2-6.4) for uveal melanoma. The age-adjusted incidence rates for uveal melanoma between 2001 2017 appear to be decreasing with an annual percentage change of -0.4% (p<0.05, 95%CI: -0.8%-0.0%)Conclusions:Between 2001 – 2017 there was a decrease in incidence rates for uveal melanoma, but more research and investigations are needed. Key Words: Uveal, Ocular, Melanoma, Incidence, Epidemiology, Oncology, SEER, NPCR |